To list an item to eBay using the Multi-Variation listing format, there are two requirements that must be met:
1. The eBay category must allow this listing format
2. The Highwire product must use Options
Options in Highwire can only be added when a product is initially created. To add Options to a new product, on the Inventory & Options tab check the box next to 'This product has multiple options.'. Then add the Option Name and Option Values before saving the product. The complete tutorial on adding a new product is here.
Example Option Names would be Size, Color, etc.
Example Option Values would be Small, Medium, Large, Red, White, Blue, etc.
Once a product has options, the multi-variation listing format will be available on the eBay Settings tab of the product. The multi-variation listing format is not available in a Listing Profile.